The book is a journey of a socially awkward professor of genetics on his quest to find out if he is prepared for romance. When someone confronts his capability of being a wonderful husband, he sets out upon The Wife Project. Approaching the study in an evidence based manner, he arrives on various conclusions. Meanwhile the character Rosie is everything he concluded for a life partner. They both seek out on a mission to find her biological father, where the professor discovers his romantic feelings for her.